PREMEDICATION WITH SLOW RELEASE MORPHINE (MST) AND ADJUVANTS
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of controlled release morphine (MST) in patients with liver carcinoma.
BACKGROUND There are no studies reported on the pharmacokinetics of controlled release morphine (MST) in patients with hepatocellular carcinoma, the fifth most common cancer in the world. METHODS We have studied the pharmacokinetic profile of MST (30 mg) in 15 patients with liver carcinoma (eight with primary carcinoma on top of chronic hepatitis C, and seven with secondary metastatic liver m...
متن کاملRespiratory effects and amnesia after premedication with morphine or lorazepam.
Lorazepam, a new benzodiazepine, was compared with morphine for premedication. Ten patients received morphine 10 mg/70 kg i.m. and 10 received lorazepam 4 mg/70 kg i.m. Respiratory effects were assessed from the change in slope (S) and intercept (B) of the carbon dioxide response line, using a development of Read's rebreathing method. Morphine depressed S by 47% (P less than 0.01), but after lo...
متن کاملRelative bioavailability of controlled release morphine tablets (MST continus) in cancer patients.
The bioavailability of oral controlled release morphine tablets (MST, Napp Laboratories) and oral morphine sulphate in aqueous solution (MSS) was compared in 10 patients with advanced cancer. Serum samples were analysed for morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) using a specific HPLC assay. The relative bioavailability of morphine with MST was significantly less...
متن کاملEffect of filtration on morphine and particle content of injections prepared from slow-release oral morphine tablets
BACKGROUND Injections of mixtures prepared from crushed tablets contain insoluble particles which can cause embolisms and other complications. Although many particles can be removed by filtration, many injecting drug users do not filter due to availability, cost or performance of filters, and also due to concerns that some of the dose will be lost. METHODS Injection solutions were prepared fr...
متن کاملPharmacokinetics and analgesic effect of slow-release oral morphine sulphate in volunteers.
Sustained-release oral morphine sulphate (MST) 20 mg was administered to 11 healthy volunteers. Mean peak plasma morphine concentration was 14.8 ng ml-1, and occurred at a mean time of 142.5 min after ingestion. Analgesia assessed by an ischaemic forearm pain test increased to a maximum approximately 40 min after the calculated peak plasma concentration of morphine had been achieved, and remain...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1988
ISSN: 0007-0912
DOI: 10.1093/bja/60.7.825